Pipeline

C4Diagnostics is always searching for new ways to improve diagnostics via new products based on its technology.

After two products focused on Legionnaires’ disease, C4Diagnostics’ team plans to move forward addressing other medical needs by targeting Antibiotic Susceptibility systems and Urinary Tract Infection.

C4AST

Antiobiotic resistance

According to the CDC (Center for Disease, Control and Prevention), the Antibiotic resistance is: “when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. That means the germs are not killed and continue to grow.” All illness can be affected by antibiotic resistance, which mean every patient can be affected. 

Key Figures

of mis-prespictions per year in US hospitals

deaths per year caused by antibiotic resistance in Europe

%

increase in mortality per hour delay in adequatly treating sepsis

annual overall cost in the US

Legionella Pneumophila in lugs, 3D

C4AST Kit

The C4AST kit is currently under development. It is composed of an automated system to test isolated colony on their antibiotic resistance.

Product design to reduce by 5 times the time to results, which is consequent knowing that every hour, some illness like sepsis gain 4% of mortality rate.

Next generation: run tests directly on blood samples.

C4UTI

Urinary Tracts Infection detection

UTI conditions

Urinary tracts is the most common infection localisation. Most of the cases of UTI are uncomplicated, easily treated and caused by only one type of bacteria. Escherichia coli is responsible for 75% to 95 % of cases, but UTI can also be caused by Klebsiella pneumoniae, Streptococcus, Staphylococcus

Most of the tests for UTI conditions are done in labs and 70 to 80% of the tests are negatives.

Publication quotes

In 2007, in the United States alone, there were an estimated 10.5 million office visits for UTI symptoms […] and 2–3 million emergency department visits. Currently, the societal costs of these infections, including health care costs and time missed from work, are approximately US $3.5 billion per year in the United States alone.

A. L. Flores-Mireles & al. Nat Rev Microbiol. 2015 May ; 13(5): 269–284. doi:10.1038/nrmicro3432

Approximately 15% of all community-prescribed antibiotics in the US are dispensed for UTI and data from some European countries suggest a similar rate. In the US, UTIs account for > 100,000 hospital admissions annually […]

M. Grabe & al. Guidelines on Urological Infections, European Association of Urology 2015

Urinary tract infection (UTI) is a widespread disease, and thus, the most common samples tested in diagnostic microbiology laboratories are urine samples. The “gold standard” for diagnosis is still bacterial culture, but a large proportion of samples are negative. Unnecessary culture can be reduced by an effective screening test.

B. Pierreti & al. Journal of Clinical Microbiology, Nov. 2010, p. 3990–3996

Legionella Pneumophila in lugs, 3D

C4UTI Kit

The C4Diagnostics’ technology allows a rapid screening (positive vs. negative) of urine samples: a few hours instead of 24 hours currently. That allows to start the complete process of culture – identification and AST only for the urine samples requiring it, thus greatly reducing “unnecessary” logistic and human resources issues and costs related to the volumes of Petri dishes used.

By using C4UTI, those cultures don’t need to be done. That product allows laboratory costs reduction and also, a reduction of unnecessary antibiotic use.

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